A large-scale dataset of pre- and post-surgical MRI data in patients with chronic trigeminal neuralgia

This dataset includes raw neuroimaging data from the neuroimaging of primary trigeminal neuralgia study, collected at the Federal Neurosurgical Center, Novosibirsk, Russia.
Data were collected between 2022 and 2025. Participants were adults with diagnosed primary trigeminal neuralgia (according to The International Classification of Headache Disorders criteria), as well as healthy volunteers.

This dataset includes high-resolution 3D_T1w_TFE, 3D_T2w, DTI with 64 diffusion directions and resting-state bold-fMRI data. Anatomical scans were defaced using pydeface software.

MRI data were collected for 119 patients with PTN, organized in folders labeled sub-000, and 53 healthy volunteers in folders labeled sub-00. Furthermore, follow-up MRI data are available for 64 patients, stored in folders labeled sub-000fu. A second follow-up (via telephone interview) is available for 93 patients.

Clinical, demographic and treatment-related information for each participant is provided in the participants.tsv file. A brief description of the columns is as follows:

BIDS_ID: Participant identifier (e.g., sub-009 for patients, sub-01 for controls).

age, sex, BMI, Racial/ethnic category: Basic demographic and anthropometric data.

Clinical_finding: Primary diagnosis (e.g., TN, SUNA, SUNCT, or "normal" for controls).

MRI_finding: Summary of key radiological findings (e.g., NVC, Fazekas grade, other anomalies).

Sindou_grade: Neurovascular compression grade according to the Sindou classification (where applicable).

Pain_side, Pain_type, Pain_severity, Disease_duration: Characteristics of the pain condition.

Pharm_treatment: Pharmacological treatment details, including drug names and daily doses.

Previous_surgeries, Previous_surgery_type: History of prior surgical interventions for TN.

Surgery_type, Surgery_outcome, Postsurgery_pain_reduction, Surgical_complications: Details of the current surgical procedure (MVD, PI) and its immediate results.

First follow-up, First follow-up time: Availability and timing (in days) of the first clinical follow-up (median time: 245 days).

Second follow-up, Second follow-up pain NRS, Second follow-up time: Availability, pain score (0-10), and timing (in days) of the second follow-up (median time: 568 days).

Comorbid medical conditions: List of reported comorbid health conditions.

Additionally, the participants_psychology file contains data from psychological and neuropsychological testing for 84 patients and 47 healthy volunteers.

The "mriqc_data" folder contains information on image quality metrics for T1w, T2w, DWI, and BOLD images calculated in a group analysis format for all patients. Raw data for each patient is available upon request to the dataset authors.

本数据集包含来自俄罗斯新西伯利亚联邦神经外科中心开展的原发性三叉神经痛（primary trigeminal neuralgia, PTN）神经影像学研究的原始神经影像数据。数据采集时间为2022年至2025年。研究对象为符合《国际头痛疾病分类》诊断标准的原发性三叉神经痛成年患者，以及健康志愿者。

本数据集包含高分辨率3D_T1w_TFE序列影像、3D_T2w序列影像、包含64个扩散方向的弥散张量成像（diffusion tensor imaging, DTI）数据以及静息态血氧水平依赖功能磁共振成像（resting-state blood-oxygen-level dependent functional MRI, BOLD-fMRI）数据。解剖影像已通过pydeface软件完成面部去标识操作。

本研究纳入119例原发性三叉神经痛患者，数据以sub-000命名的文件夹存储；53例健康志愿者的数据以sub-00命名的文件夹存储。此外，64例患者拥有随访磁共振影像数据，存储于sub-000fu命名的文件夹中。另有93例患者拥有通过电话访谈获取的二次随访数据。

所有受试者的临床、人口统计学及治疗相关信息均存储于participants.tsv文件中，各字段简要说明如下：
BIDS_ID：受试者标识符（例如患者为sub-009，健康对照为sub-01）。
age（年龄）、sex（性别）、BMI（身体质量指数）、Racial/ethnic category（种族/族群类别）：基础人口统计学与人体测量学数据。
Clinical_finding：初步诊断结果（例如TN、SUNA、SUNCT，健康对照标注为“normal”）。
MRI_finding：影像学关键发现总结（例如神经血管压迫（neurovascular compression, NVC）、Fazekas分级及其他异常）。
Sindou_grade：基于Sindou分级标准的神经血管压迫等级（若适用）。
Pain_side（疼痛侧别）、Pain_type（疼痛类型）、Pain_severity（疼痛程度）、Disease_duration（病程时长）：疼痛相关临床特征。
Pharm_treatment：药物治疗详情，包括药物名称与每日给药剂量。
Previous_surgeries（既往手术史）、Previous_surgery_type（既往手术类型）：三叉神经痛既往外科干预史。
Surgery_type（手术类型）、Surgery_outcome（手术结局）、Postsurgery_pain_reduction（术后疼痛缓解情况）、Surgical_complications（手术并发症）：本次外科手术（微血管减压术（microvascular decompression, MVD）、经皮介入手术（percutaneous intervention, PI））的相关信息及即刻疗效。
First follow-up（首次随访）、First follow-up time（首次随访时间）：首次临床随访的可获得性及随访时长（单位：天，中位随访时间为245天）。
Second follow-up（二次随访）、Second follow-up pain NRS（二次随访疼痛数字评分量表（Numerical Rating Scale, NRS）评分）、Second follow-up time（二次随访时间）：二次随访的可获得性、疼痛评分（0~10分）及随访时长（单位：天，中位随访时间为568天）。
Comorbid medical conditions：报告的共病健康状况列表。

此外，participants_psychology文件包含84例患者与47例健康志愿者的心理学及神经心理学测试数据。

“mriqc_data”文件夹包含针对所有受试者的T1w、T2w、DWI及BOLD影像的图像质量指标信息，以组分析格式计算得出。每位受试者的原始影像数据可通过向数据集作者提交申请获取。

搜集汇总

背景与挑战

背景概述

这是一个大型神经影像数据集，专注于慢性三叉神经痛患者，包含119名患者和53名健康志愿者的手术前后多模态MRI数据（如3D_T1w、DTI和静息态fMRI），收集于2022年至2025年。数据集特点包括长期随访（首次和第二次随访）、丰富的临床和人口统计学信息，以及心理测试数据，旨在支持神经痛研究和治疗评估。