Directed, Palladium(II)-Catalyzed Intermolecular Aminohydroxylation of Alkenes Using a Mild Oxidation System
收藏Figshare2018-06-12 更新2026-04-29 收录
下载链接：
https://figshare.com/articles/dataset/Directed_Palladium_II_-Catalyzed_Intermolecular_Aminohydroxylation_of_Alkenes_Using_a_Mild_Oxidation_System/6473132
下载链接
链接失效反馈官方服务：
资源简介：
A palladium(II)-catalyzed β,γ-aminohydroxylation reaction of nonconjugated alkenyl carbonyl compounds has been developed. This reaction utilizes a cleavable bidentate directing group to achieve regioselective aminopalladation. The resulting chelation-stabilized alkylpalladium(II) intermediate is then hydroxylated using oxygen/2,6-dimethylbenzoquinone in HFIP as the mild oxidation system. Under the optimized conditions, various nucleophiles and alkene substrates are capable of delivering good yields and high diastereoselectivities of the aminohydroxylated products.
创建时间：
2018-06-12
