LC-MS/MS and GC-MS/MS cross-checking analysis method for 247 pesticide residues in sweet pepper (<i>Capsicum annuum</i>)

A simultaneous analysis method using LC-MS/MS and GC-MS/MS was developed for improving the analysis accuracy of various pesticide residues. Samples spiked with 247 and 34 pesticide residues were analyzed by LC-MS/MS and GC-MS/MS, respectively. The method was verified by measuring sensitivity, linearity, selectivity, precision, and accuracy. LC-MS/MS LOD and LOQ values were determined to be 0.03–0.5 μg/kg, and 0.6–1.5 μg/kg, respectively, while the corresponding values for GC-MS/MS were found to be 0.9–2.0 μg/kg and from 3.0–5.7 μg/kg, respectively. Most of the 34 common residues had recovery rates of 70–120%. The results showed that the developed method can be a reliable and more accurate than the general multi component analysis method.