A transcriptome atlas of spleen defines B lymphocytes as strategy to prevent ocular infection of herpes simplex virus-1

Herpes simplex virus-1 (HSV-1) is the major pathogen causing viral keratitis. Spleen plays a vital role in locally and systemically modulating innate and adaptive immunity. However, the underlying connection between spleen and ocular HSV-1 infection remains uncertain. Overall design: They were divided into two groups: nor group and HSK Group. There were four nor groups in one group.