Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases

Interstitial lung diseases (ILD) are characterized by fibrotic scarring of the distal lung parenchyma with remarkably unfavorable prognosis. Here we generated a comprehensive portrait of diverse cell types in distal lung and investigated how their spatial organization is altered in fibrosis. We provide the cloupe files for each individual Visium run which can be visualized using the Loupe browser. Each file also contains additional metadata on community membership and annotated histopathological feature for each visium spot overlaid on top of the H&E stained image.