Molecular status of diagnosis total AML and sorted stem cell fractions from the same BM.

§signal originating from the bulk of the leukemic blasts has been used for reference. Sorted lymphocytes from the same BM showed no molecular aberrancies. *Aberrant markers with the highest coverage of the CD34+CD38- compartment were used for sorting HSC (aberrant marker negative) and pLSC (aberrant marker positive). ¥Shown in Figure 1. #For FLT3-ITD+ cases, the percentage of ITD of the total signal is indicated. $Median frequency of HSCs (46.5% of CD34+CD38- compartment) was higher than the median in a larger group of cases (median 18%), since cases in this table had to be selected on clear availability of both HSCs and pLSCs. Abbreviations: wt, wild type: no FLT3-ITD or NPM1 peak present; mut: mutation of NPM1 (not quantitative), neg: negative, pos: positive, BM: bone marrow. Molecular status of diagnosis total AML and sorted stem cell fractions from the same BM.