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Heterodimers of Aromadendrane Sesquiterpenoid with Benzoquinone from the Chinese Liverwort <i>Mylia nuda</i>

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NIAID Data Ecosystem2026-05-01 收录
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Mylnudones A–G (1–7), unprecedented 1,10-seco-aromadendrane-benzoquinone-type heterodimers, and a highly rearranged aromadendrane-type sesquiterpenoid (8), along with four known analogs (9–12), were isolated from the liverwort Mylia nuda. Compounds 1–6 and 7, bearing tricyclo[6.2.1.02,7] undecane and tricyclo[5.3.1.02,6] undecane backbones, likely formed via a Diels–Alder reaction and radical cyclization, respectively. Their structures were determined by spectroscopic analysis, computational calculation, and single-crystal X-ray diffraction analysis. Dimeric compounds displayed cytoprotective effects against glutamic acid-induced neurological deficits.

创建时间:
2023-12-29
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