A CASE OF DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORIN AN ADOLESCENT MALE

Dysembryoplastic neuroepithelial tumors (DNETs) are low grade glioneuronal tumors frequently occurring in the pediatric population and in young adults. The correct diagnosis is based on Magnetic resonance Imaging, Immunohistochemistry, and identification of fibroblast growth factor receptor 1 and BRAF V600E mutations. These tumors are considered non-recurring lesions and gross total surgical resection are curative with disappearance of seizuresin up to 100% of cases. We report a 13-year-old male patient who was admitted to the emergency department for a generalized seizure, with a 5-year-history of iterative complex partial seizures for which he has been receiving valproic acid, with no improvement. A Magnetic Resonance Imaging was performedrevealing a 14x12mm, oval-shaped, circumscribed solido-cystic lesion, of the left fronto-parietal lobes cortex. A ring enhancing appearance could be also identified.Pathological assessment has revealedthe presence of a low-cellularity neoplastic proliferation made of round, uniform, mildly atypical cells, in an abundant myxoid stroma that contained numerous bundles of axons. Floating neurons were also observed. Follow-up of the patient showed a favorable evolution with complete disappearance of any seizures anti-convulsive therapy has been stopped.Follow-up MRI surveillance is planned in our patient.