G4Atlas: a comprehensive transcriptome-wide G-quadruplex database

G4Atlas is a transcriptome-wide G-quadruplex database containing and visualising transcriptome RNA G-quadruplex (rG4) experimental data, generated from rG4-seq, chemical profiling and ligand-binding methods. rG4 is a vital RNA tertiary structure motif that involves the base pairs on both Hoogsteen and Watson-Crick faces of guanines, and is relevant to the post-transcriptional regulation of gene expression. RNA secondary structure prediction information across both experimentally identified and unidentified rG4s is also included to enable users to display any potential competitive folding between rG4 and RNA secondary structures. As such, G4Atlas allows users to explore the general functions of rG4s in diverse biological processes, and provides a starting point for further data-driven deep learning algorithms to examine rG4 structural features.G4Atlas是一款全转录组层面的G四链体（G-quadruplex）数据库，用于收录并可视化基于rG4测序（rG4-seq）、化学谱分析及配体结合实验方法所获得的转录组水平RNA G四链体（rG4）实验数据。rG4是一类关键的RNA三级结构基序，其形成涉及鸟嘌呤的胡斯坦（Hoogsteen）面与沃森-克里克（Watson-Crick）面所参与的碱基配对，与基因表达的转录后调控密切相关。数据库同时收录了经实验鉴定与未被鉴定的rG4对应的RNA二级结构预测信息，以支持用户可视化展示rG4与RNA二级结构之间潜在的竞争性折叠现象。借此，G4Atlas可助力用户探索rG4在多样生物学过程中的核心功能，并为后续基于数据驱动的深度学习算法解析rG4结构特征提供基础起点。

搜集汇总

背景与挑战

背景概述

G4Atlas是一个全面的转录组范围G-四链体数据库，整合并可视化来自rG4-seq、化学探测和配体结合方法的RNA G-四链体实验数据。该数据库包含RNA二级结构预测信息，支持用户探索rG4在生物过程中的功能，并为基于数据的深度学习算法提供基础。