Identifying the Role of Neutrophils and Myeloperoxidase in a Zebrafish Model of DMD

Duchenne Muscular Dystrophy is a severe and progressive muscle disease. Muscle failure is caused by structural defects, but the failing muscle also triggers an immune response that can exacerbate damage. In this thesis I explore the role of neutrophils, a component of the immune system, in contributing to muscle damage using a zebrafish disease model. I identify a key enzyme that contributes to muscle damage and show that muscle is improved by its removal. Additionally, I identify a drug that removes this enzymes function which can now be explored as a treatment for DMD.