Crystal structure of CHK1-10pt-mutant complex with compound 45
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Crystal structure of CHK1-10pt-mutant complex with compound 45 Descriptor: 4-amino-7-methyl-2-({5-methyl-1-[(3S)-oxolan-3-yl]-1H-pyrazol-4-yl}amino)-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, CHLORIDE ION, Serine/threonine-protein kinase Chk1 Authors: Dokurno, P, Surgenor, A.E, Williamson, D.S. Deposit date: 2021-01-15 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate. J.Med.Chem., 64, 2021
创建时间：
2021-01-15
