scRNA-seq of Abdominal aortic aneurysm tissues in Gsdme-KO mice

The aim of this study was to explore the transciptome of the diverse vascular smooth muscle cells subsets from abdominal aortic aneurysm tissues in Gsdme deletion mice.The model was established by exposing the infrarenal aorta to PPE (porcine pancreatic elastase) under pressure to induce aneurysmal degeneration for 4 weeks.we compared the characteristics of SMC subpopulation beteew the WT and KO groupsto reveal the effect of GSDME in the progression of Abdomanl Aortic Aneurysm. Overall design: AAA model was established by PPE infusion. The control group mice is C57BL/6J,the model group mice is Gsdme global deletion.the analysed sample was abdominal aorta.