Spatial profiling of human pancreas during type 1 diabetes progression

Spatial transcriptomic profiling on the CosMx platform (NanoString, Seattle, WA). Pancreatic tissue from six nPOD organ donors - three with T1D (6228, 6247, 6456) and three without diabetes (6431, 6339, 6229), matched by age and sex. For each donor, five consecutive FFPE tissue sections from the pancreatic body region were cut at a thickness of 4 microns.