Notch2 in mesenchymal stromal cells regulates canonical Wnt signalling in CLL cells. Mus musculus

We used microarrays to investigate differential gene expression in mouse bone marrow derived mesenchymal stromal cells, proficient or deficient for Notch2, cultured for 5 days in the presence or absence with primary CLL cells from 6 patients Overall design: Notch2 pro- and deficient MSCs were co-cultured with 6 individual primary CLLs