NOD pathway

The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori.

NOD（核苷酸结合寡聚化结构域）蛋白NOD1和NOD2在先天免疫系统中扮演着至关重要的角色，它们作为细菌肽聚糖来源的微生物成分的传感器发挥作用。这些分子的重要性不容忽视，因为编码NOD2的基因突变在克罗恩病患者的亚群中有所发现，同时NOD1也被证实参与了宿主对幽门螺杆菌感染的防御机制。