Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy

Regulatory Mechanisms of Atrial Remodeling of Human Mitral Regurgitation This study enrolled 10 human subjects and divided into two groups: mitral regurgitation patients (MR) (n = 7; 7 females), and normal control subjects (NC) (n= 3).We sought to systemically elucidate critical differences in the alteration of RNA expression pattern between the atrial myocardium of MR patients and normal subjects using high-density oligonucleotide microarrays and functional network enrichment analysis.