Identification of Neuronal Pentraxin II as a key component in the regulation of anxiety

We report that hippocampal neuronal pentraxin 2 (Nptx2) plays an important role in mediating anxiety. To better understand the mechanism of how Nptx2 alters anxiety, we detected the differential hippocampal gene expression between Nptx2 WT and KO. To do so, we took Nptx2 WT and KO (n = 3) mice for RNA-sequencing (RNAseq)