Range of SARS-CoV-2% memory B cells among participants with hybrid immunity, by number of spike exposure*—Georgia, December 2020– July 2022, n = 15.

*Spike exposure is defined as exposure to the viral spike protein due to either a SARS-CoV-2 infection(s) or a dose(s) of an mRNA COVID-19 vaccine receipt. The primary series was considered as two spike exposures. †Hybrid immunity was defined as the immune protection in individuals who have had one or more doses of an mRNA COVID-19 vaccine and have evidence of at least one SARS-CoV-2 infection before or after vaccination initiation. ‡ A moderate or severely immunocompromising condition included the following: recent or active malignancy, bone marrow transplant, solid organ transplant, primary or secondary immune deficiency, or the use of oral or intravenous steroids for more than a month or any immunosuppressant drugs. (XLSX)