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3,3',5-Triiodothyroacetic acid (TRIAC) induces embryonic ?-globin expression via thyroid hormone receptor a (ChIP-seq)

NIAID Data Ecosystem2026-05-01 收录

甲状腺激素受体α靶基因

珠蛋白基因表达调控

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP303805 数据链接链接失效反馈

官方服务：

资源简介：

To characterize genome-wide THRA traget genes in K562 cells. Overall design: Examination of THRA traget genes in K562 cells.

应用场景：

创建时间：

2024-04-02

β-血红蛋白病基因治疗

珠蛋白基因表达调控

We have identified putative repressor region (PRR) to exon-1 of β-globin (βE1) in the β-globin cluster as a core region in alll the HPFH deletions that activates fetal hemoglobin and silences adult he

NIAID Data Ecosystem80

Growth factor independence 1b (Gfi1b) is required for erythroid cell maturation and regulates embryonic globin expression

红细胞生成调控

珠蛋白基因表达调控

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem50

The embryo-larval and adult parts of the zebrafish major alpha/beta-globin gene locus are functionally and structurally independent. Danio rerio

染色质构象

珠蛋白基因表达调控

We have demonstrated that, in developing Danio rerio, the embryo-larval and adult subloci of the major globin locus acquire stage-specific hyperacetylation of histone H3 and that H3 hyperacetylation p

NIAID Data Ecosystem50

Natural regulatory mutations elevate fetal globin via disruption of BCL11A or ZBTB7A binding

珠蛋白基因表达调控

遗传病基因治疗

B-hemoglobinopathies such as Sickle Cell Disease (SCD) and b-thalassemia result from mutations in the adult b-globin gene. Reactivating the developmentally silenced fetal g-globin gene is a therapeuti

NIAID Data Ecosystem60

Disrupting the adult-globin promoter alleviates promoter competition and reactivates foetal-globin gene expression

血红蛋白病基因治疗

珠蛋白基因表达调控

The benign condition Hereditary Persistence of Foetal Haemoglobin (HPFH) is known to ameliorate symptoms when co-inherited with beta-haemoglobinopathies, such as sickle cell disease and beta-thalassae

NIAID Data Ecosystem50

3,3',5-Triiodothyroacetic acid (TRIAC) induces embryonic ?-globin expression via thyroid hormone receptor a (ChIP-seq)

资源简介：

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