3-D structural locations of PGI amino acid sites in a range of organisms.

aAmino acid sites that have been proposed as being potential targets of selection.bFour functionally important human PGI amino acid sites that share similar locations to the two candidate targets of positive selection in F. ovina are also included in the table [36], [37].cThe location of the amino acid site was identified in the present study, but see ddThe locations of the amino acid sites 372 and 375 in M. cinxia and of the sites 369 and 375 in C. eurytheme were identified in earlier studies [11], [15].ePGI 3-D protein structures that have been used, in the present study, for identifying the locations of the amino acid sites listed in the second column.fBecause the majority of the PGI amino acid sequence is not available for L. stylosa, the homology-modeled PGI 3-D structure from the related L. crassa was used as a proxy (see Material and Methods).3-D structural locations of PGI amino acid sites in a range of organisms.