Epigenetic modifiers are promising targets to improve therapies in patients with cancer. Targeting the methyltransferase DOT1L with small molecule inhibitors has shown promising effects on the control
Imaging data across Embryonic Stages from Figure S7 of "Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila" by Fitz-James et al.
The methylation enrichment was determined by MIRA-sequencing after MBD2-capture using the MethylCollector™ Ultra Kit (Active Motif) performed on DNA samples derived from immortallized human myoblasts.
Transposable elements (TEs) are largely inactive. Interestingly, a subset of TEs are naturally expressed in the vegetative cell (VC) of the male gametophyte, pollen in Arabidopsis. However, the extent