Epigenetic changes in amygdala and cortex of fear-conditioned and ErbB4 Knock-out mice. Epigenetic changes in amygdala and cortex of fear-conditioned and ErbB4 Knock-out mice

Chromatin accessibility provides an important window into the regulation of gene expression. Recently, the Assay of Transposase Accessible Chromatin with sequencing (ATAC-seq) was developed to profile genome-wide chromatin accessibility. Here we applied a read-downsampling approach to call robust ATAC-seq peaks in order to profile the regions of differential chromatin accessibility of central amygdala and cortex between different experimental conditions; fear-conditioned vs. control mice and ErbB4 knock-out vs. wild-type mice. Overall design: Amygdala and cortex of 18 mouse samples under two experimental conditions 1) fear-conditioned and control and 2)ErbB4 knockout in SOM+ cells and wildtype