Atopic Dermatitis GWAS meta-analysis summary statistics

Multi-ancestry GWAS meta-analysis on 12 cohorts comprising a total of 56,146 AD cases and 602,280 controls of European (EUR), Asian (ASN), African (AFR), American (AMR) and admixed ancestries (AD_GWAS_12meta_FE_hg38_final.txt.gz).
Ancestry-stratified GWAS statistics were obtained by performing an analogous meta-analysis strategy considering cohorts stratified by continental populations: EUR, ASN, AFR (AD_GWAS_EUR_meta_FE_hg38_final.txt.gz, AD_GWAS_ASN_meta_FE_hg38_final.txt.gz, AD_GWAS_AFR_meta_FE_hg38_final.txt.gz).
GWAS meta-analysis statistics were obtained by fixed-effect (FE) inverse variance weighted meta-analysis of the summary statistics (beta values) from each cohort using GWAMA. Genomic locations provided for human genome build 38 and hg19 (see column headers).
GWAS meta-analysis design:Meta-analysis
# cohorts
Ancestry
# Cases
# Controls
# GWS loci
Lambda GC (all variants)
Multi-ancestry
12
EUR, EAS, CSA, SAS, AFR, AMR
56146
602280
94
1.054968
EUR-only
4
EUR
42963
408472
76
1.089119
ASN-only
4
ASN
5014
171135
12
1.054628
AFR-only
2
AFR
7063
15879
0
1.016833
Each file contains the following column headers:
CHR: hg38 marker chromosome
POS: hg38 marker position (bp)
REF: reference allele
ALT: effect allele
MARKER: marker in format chr:pos:ref:alt (hg38, ex. 1:10177:A:AC)
rsID: dbSNP rsID
PVAL: meta-analysis p-value
BETA: overall beta value for meta-analysis
SE: beta standard error
Z: Z-score
ALT_AF: alternate/effect allele frequency
n_studies: number of studies with marker present
n_samples: number of samples with marker present
effects: summary of effect directions ('+' - positive effect of ALT allele, '-' - negative effect of ALT allele, '0' - no effect (or non-significant) effect of ALT allele, '?' - missing data)
hg19_CHR: hg19 marker chromosome
hg19_POS: hg19 marker position
q_statistic: Cochran's heterogeneity statistic
q_p-value: Cochran's heterogeneity statistic's p-value
i2: Heterogeneity index I2 by Higgins et al 2003