Atopic Dermatitis GWAS meta-analysis summary statistics

Multi-ancestry GWAS meta-analysis on 12 cohorts comprising a total of 56,146 AD cases and 602,280 controls of European (EUR), Asian (ASN), African (AFR), American (AMR) and admixed ancestries (AD_GWAS_12meta_FE_hg38_final.txt.gz). Ancestry-stratified GWAS statistics were obtained by performing an analogous meta-analysis strategy considering cohorts stratified by continental populations: EUR, ASN, AFR (AD_GWAS_EUR_meta_FE_hg38_final.txt.gz, AD_GWAS_ASN_meta_FE_hg38_final.txt.gz, AD_GWAS_AFR_meta_FE_hg38_final.txt.gz). GWAS meta-analysis statistics were obtained by fixed-effect (FE) inverse variance weighted meta-analysis of the summary statistics (beta values) from each cohort using GWAMA. Genomic locations provided for human genome build 38 and hg19 (see column headers). GWAS meta-analysis design:Meta-analysis # cohorts Ancestry # Cases # Controls # GWS loci Lambda GC (all variants) Multi-ancestry 12 EUR, EAS, CSA, SAS, AFR, AMR 56146 602280 94 1.054968 EUR-only 4 EUR 42963 408472 76 1.089119 ASN-only 4 ASN 5014 171135 12 1.054628 AFR-only 2 AFR 7063 15879 0 1.016833 Each file contains the following column headers: CHR: hg38 marker chromosome POS: hg38 marker position (bp) REF: reference allele ALT: effect allele MARKER: marker in format chr:pos:ref:alt (hg38, ex. 1:10177:A:AC) rsID: dbSNP rsID PVAL: meta-analysis p-value BETA: overall beta value for meta-analysis SE: beta standard error Z: Z-score ALT_AF: alternate/effect allele frequency n_studies: number of studies with marker present n_samples: number of samples with marker present effects: summary of effect directions ('+' - positive effect of ALT allele, '-' - negative effect of ALT allele, '0' - no effect (or non-significant) effect of ALT allele, '?' - missing data) hg19_CHR: hg19 marker chromosome hg19_POS: hg19 marker position q_statistic: Cochran's heterogeneity statistic q_p-value: Cochran's heterogeneity statistic's p-value i2: Heterogeneity index I2 by Higgins et al 2003