Phosphoketolase from B. bifidum-Derived Outer Membrane Vesicles Enhances Anti-TNF Therapy in IBD Patients by Promoting Histone Lactylation in Macrophages
Pharmacological inhibition of NLRP3 inflammasome activation may offer a new option in the treatment of inflammatory bowel disease. In this work, we report the design, synthesis, and biological screeni
Lactobacillus casei (L. casei), a normal resident of the gastrointestinal tract of mammals, has been extensively studied over the past few decades for its probiotic properties in clinical and animal m
Indigo naturalis (IN), a traditional Chinese medicine derived from indigo plants, has been widely used in the treatment of UC. We evaluated the effects and mechanisms of IN in dextran sulfate sodium (
NLRP3, a crucial member of the NLRP family, plays a pivotal role in immune regulation and inflammatory modulation. Here, we report a potent and specific NLRP3 inhibitor Z48 obtained though docking-bas
