Transcriptome analysis of polymorphic p53 codon 72 under genotoxic stress

We report the transcriptome data produced from isogenic polymorphic p53 codon 72 iPSCs under doxorubicin treatment. By inserting BAC DNA into one allele of the heterozygous polymorphic p53 codon 72, each clone expressed a p53 protein encoding P72 or R72 from another allele in which it was not inserted. The transcriptional regulation of p53 target genes was compared between the isogenic lines under doxorubicin treatment. Overall design: One set of RNA seq data was prepared from P72, R72 or p53 null human iPSCs under 0.2 µM doxorubicin treatement for 2 or 4 hrs.