HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound.
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HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound. Descriptor: (2R)-({N-[(3S)-3-({[(3S,6S)-6-CYCLOHEXYL-5,8-DIOXO-4,7-DIAZABICYCLO[14.3.1]ICOSA-1(20),16,18-TRIEN-3-YL]CARBONYL}AMINO)-2-OXOHEXANOYL]GLYCYL}AMINO)(PHENYL)ACETIC ACID, BETA-MERCAPTOETHANOL, NS3 protease/helicase', ... Authors: Chen, K.X, Njoroge, F.G, Prongay, A, Pichardo, J, Madison, V, Girijavallabhan, V. Deposit date: 2005-06-29 Release date: 2006-07-04 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease Bioorg.Med.Chem.Lett., 15, 2005
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2005-06-29
