In the cell, stalled ribosomes are rescued through ribosome-associated protein quality-control (RQC) pathways. We demonstrate that RqcH is responsible for tRNAAla selection during RQC elongation, wher

NIAID Data Ecosystem60

Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation

内质网相关降解

蛋白质质量控制

Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transpor

Figshare2019-01-25 更新20

Genome-wide CRISPR-Cas9 screen (TKOv3) data on CYP51A1TM degradation

蛋白质质量控制

ERAD途径

Misfolded proteins in the endoplasmic reticulum (ER) are degraded by ER-associated degradation (ERAD). While ERAD components involved in degradation of luminal substrates are well-characterized, much

NIAID Data Ecosystem70

Cryo-EM structure of Hrd1/Hrd3 monomer

蛋白质结构

ERAD途径

Cryo-EM structure of Hrd1/Hrd3 monomer Descriptor: ERAD-associated E3 ubiquitin-protein ligase HRD1, ERAD-associated E3 ubiquitin-protein ligase component HRD3 Authors: Wu, X, Rapoport, T.A. Deposit d

Protein Data Bank Japan2024-03-06 更新60

The ERAD misfolded glycoprotein checkpoint complex from Chaetomium thermophilum (EDEM:PDI heterodimer).

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