Asymmetric Synthesis of 2‑Substituted Azetidin-3-ones via Metalated SAMP/RAMP Hydrazones
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https://figshare.com/articles/dataset/Asymmetric_Synthesis_of_2_Substituted_Azetidin-3-ones_via_Metalated_SAMP_RAMP_Hydrazones/3546744
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资源简介:
2-Substituted azetidin-3-ones
can be prepared in good yields and
enantioselectivities (up to 85% ee) by a one-pot procedure involving
the metalation of the SAMP/RAMP hydrazones of N-Boc-azetidin-3-one,
reaction with a wide range of electrophiles, including alkyl, allyl,
and benzyl halides and carbonyl compounds, followed by hydrolysis
using oxalic acid.
创建时间:
2016-08-29



