Age-associated alteration of gene expression patterns in mouse oocytes

Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice using the NIA 22K 60-mer oligo microarray. Keywords: other母体衰老伴随卵母细胞发育能力降低，是人类不孕症的主要诱因之一。为探究小鼠模型中年龄依赖性分子变化，我们采用NIA 22K 60聚体寡核苷酸微阵列（NIA 22K 60-mer oligo microarray），对5-6周龄小鼠与40-42周龄小鼠的第二次减数分裂中期卵母细胞（metaphase II oocytes）的基因表达谱进行了对比分析。关键词：其他