five

SILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa

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NIAID Data Ecosystem2026-05-01 收录
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https://www.omicsdi.org/dataset/pride/PXD051415
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Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with the majority located on histones.
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2024-04-13
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