†Number of subjects included in PK and PD population (N (%)): 4 (67%). Samples from 2 subjects were unusable because they had thawed in transit to the analytical laboratory. Abbreviations: AE, Adverse
Compounds targeting the mediators listed in S5 Table. Columns are ‘uniprot’: UniProtID; ‘gene_symbol’: Gene Symbol; ‘target_chembl_id’: CHEMBL ID for this protein; ‘compound_id’: CHEMBL compound ID; ‘