Library ranks assigned to FDA-approved drugs in virtual screening for HIV-1 protease inhibitors.

*From: http://www.fda.gov/oashi/aids/virals.html. †CAS Registry at http://www.cas.org/. ‡Maximal Tanimoto coefficient to template-bound ligands (<35% target -template sequence identity). §Ranks assigned by FINDSITE, FINDSITELHM and these resulted from data fusion (FINDSITE/FINDSITELHM); the screening library consists of 124,363 compounds; ranks in bold and italics are within the top 5% and 1% of the library, respectively.