Mus musculus strain:B6D2F1N Transcriptome or Gene expression. Mus musculus strain:B6D2F1N

We first show that Dlx5/6 expression begins in Müllerian ducts epithelia and persists then in the uterine luminal and glandular epithelia throughout postnatal maturation and in the adult. We then use a new mouse model in which Dlx5 and Dlx6 can be simultaneously inactivated in the endometrium using a Pgrcre/+ allele. Postnatal inactivation of Dlx5/6 in the uterus results in sterility without any obvious ovarian involvement. The uteri of Pgrcre/+;Dlx5/6flox/flox mice present very few uterine glands and numerous abnormally large and branched invaginations of the uterine lumen.