首页/数据集/Loss of CREBBP results in H3K27Ac loss at enhancers and gene expression repression in lymphoma cells. Loss of CREBBP results in H3K27Ac loss at enhancers and gene expression repression in lymphoma cells

Loss of CREBBP results in H3K27Ac loss at enhancers and gene expression repression in lymphoma cells. Loss of CREBBP results in H3K27Ac loss at enhancers and gene expression repression in lymphoma cells

NIAID Data Ecosystem2026-03-09 收录

淋巴瘤表观遗传学

CREBBP基因调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA316703 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2016-03-29

淋巴瘤表观遗传学

DNA甲基化特征

We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differenc

NIAID Data Ecosystem80

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B-cell fate decisions and accelerates development of T-cell depleted lymphomas (Cut&Run)

淋巴瘤表观遗传学

细胞命运决定

Mutations in chromatin modifiers are a hallmark of many tumors, especially lymphomas arising from germinal center (GC) B cells. Given that these lymphoma mutations all induce aberrant gene repression,

NIAID Data Ecosystem40

Key Super Enhancers Drive Tumor-Suppressing Transcription Feedback Programs in Mature B Cell Cancers (ChIP-seq, FAIRE-seq). Key Super Enhancers Drive Tumor-Suppressing Transcription Feedback Programs in Mature B Cell Cancers (ChIP-seq, FAIRE-seq)

淋巴瘤表观遗传学

增强子调控

Dynamic changes to the epigenome are essential regulators of B cell differentiation and, when perturbed, can lead to cancer. We compared three types of mature B cell lymphoma/leukemia (BCL) and normal

NIAID Data Ecosystem40

Methylation and gene expression data obtained from Dnmt3b+/+, Dnmt3bD/D and Dnmt3bCI/CI MYC induced T-cell lymphomas (MTCLs).. Methylation and gene expression data obtained from Dnmt3b+/+, Dnmt3bD/D and Dnmt3bCI/CI MYC induced T-cell lymphomas (MTCLs).

淋巴瘤表观遗传学

甲基化功能研究

DNA methylation has suppressive effects on gene transcription and it is involved in a variety of physiologic processes, including development and cancer. As we and others demonstrated, Dnmt3b is a tum

NIAID Data Ecosystem60

H3K5me3 modifications in OCI-LY19 cells with and without SETD1B mutations.

淋巴瘤表观遗传学

药物耐药性

The translocation t(14;18) activates BCL2 and is considered the initiating genetic lesion in most follicular lymphomas (FL). Surprisingly, FL patients fail to respond to the BCL2 inhibitor, Venetoclax

NIAID Data Ecosystem40

Loss of CREBBP results in H3K27Ac loss at enhancers and gene expression repression in lymphoma cells. Loss of CREBBP results in H3K27Ac loss at enhancers and gene expression repression in lymphoma cells

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