FOXM1 acts sexually dimorphically to regulate functional B-cell mass (RNA-Seq)

FOXM1 increases beta cell proliferation and mass in aged male mice. Previous work also demonstates that reducing Foxm1 in the beta cell had a larger effect on male than female beta cell function. Here we investigate differences in FOXM1 action in the beta cell due to sex. Overall design: FOXM1 was expressed in female mouse beta cells (b-FOXM1 mice) or human male and human islets, and glucose tolerance, beta cell mass, beta cell proliferation, and insulin secretion were examined. Samples were sequenced and the binding sites for FOXA2, FOXM1, and ER? transcription factors were compared.