Summary of associations between SNPs in CYP2R1, GC, and DHCR7, and HCV-related hepatocellular carcinoma development.

Allele 2 indicates the risk allele, according to Wang et al. [9]. P-values and ORs were calculated for risk genotypes using favorable genotypes as a reference, i.e. for CYP2R1 by comparing GG vs. GA/AA genotypes, for GC by comparing TT/TG vs. GG genotypes, and for DHCR7 by comparing TT vs. TC/CC genotypes.#Only patients from the SCCS and Japanese GWAS were included in the combined analysis for this locus, because of the different allele frequencies for rs12785878 in Japanese patients compared to Caucasian patients. Data remain significant after inclusion of the Bonn-Berlin cohort (P = 0.018, OR = 1.27 [95% CI = 1.04–1.56]). *Genotyping of this SNP failed in the Japanese Replication cohort due to limited amounts of DNA. Please note that the total number of patients with available genotypes is not equal between different loci due to limited amount of DNA or genotyping failure in some cases.1rs1993116 and rs10741657 are in complete LD in the Caucasian and Japanese population (R2 = 0.95 and = 1.00, respectively), the major alleles of both SNPs have a similar impact on 25(OH)D3 serum levels, indicating that both SNPs can be used equivalently [9].2rs7944926 and rs12785878 are in complete LD in the Caucasian and Japanese population (R2 = 1.00 and = 1.00, respectively), the major alleles of both SNPs have a similar impact on 25(OH)D3 serum levels, indicating that both SNPs can be used equivalently [9].