In Silico Reconstruction and Domain Mapping of MERS-CoV S1-CD40L Fusion Constructs from US Patent US11219685B1: Mouse (SEQ ID NO: 11) vs. Human (SEQ ID NO: 23) CD40L Ectodomains

This dataset provides a fully reconstructed, residue-resolved annotation of the MERS-CoV S1–CD40L fusion protein sequences disclosed in US Patent US11219685B1. It includes:SEQ ID NO: 11: Full-length DNA and amino acid sequence of the murine CD40L-fused S1 construct, used in preclinical mouse studies.SEQ ID NO: 23: Human CD40L ectodomain sequence intended for clinical translation.Domains are mapped with nucleotide and amino acid coordinates, including signal peptide, S1 consensus, His-tag, T4 fibritin trimerization motif, AAA linker, and CD40L ectodomain boundaries. This resource supports translational safety assessment, immunogenicity prediction, and species-mismatch analysis in CD40-targeted vaccine design.All analysis are based on publicly disclosed parameters of the above mentioned patent.Note: This dataset is part of an ongoing series of in silico stress tests evaluating the technical claims of US Patent US11219685B1. It is intended solely for scientific research and scholarly discourse, not as legal advice or a formal challenge to patent validity.