Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.
收藏PubMed Central1995-12-05 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC40449/
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资源简介：
GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-12-05
