LFP data from epileptic mice

This database is a collection of LFP data obtained in the Lab of Prof. Dr. CA Haas (Experimental Epilepsy Research, Dept of Neurosurgery, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany). Adult transgenic male mice (C57BL/6-Tg(Thy1- eGFP)-M-Line) were injected with 50 nL of 10-20 mM kainate (Tocris, Bristol, UK) in the right dorsal hippocampus. Following KA injection the occurrence of a behavioral Status Epilepticus was verified. Teflon-coated platinum-iridium wires (125 mm diameter; World Precision Instruments, Sarasota, Florida, USA) were implanted 14-16 days after kainate injections at two to three hippocampal positions and some additionally in the entorhinal cortex. Mice were connected to a miniature preamplifier (MPA8i, Smart Ephys/Multi-Channel Systems, Reutlingen, Germany). Signals were amplified 1000-fold, bandpass-filtered from 1 Hz to 5 kHz, and digitized with a sampling rate of 10 kHz (Power1401 analog-to-digital converter, Spike2 software, Cambridge Electronic Design, Cambridge, UK). Data was downsampled to 500 Hz and seizure detection was performed semi-automated (see https://doi.org/10.1523/ENEURO.0299-18.2019). Recording IDs are encoding mouse number, recording day after KA, recording hour, recording position, recording channel. Example: EBM103_20d1_HCi1_3 (mouse: EBM103, rec day after KA: 20d, rec hour: 1, position: HCi1, channel: 3). Nomenclature of recording positions: HCi1, ipsilateral dorsal hippocampus (sclerotic); HCc, contralateral dorsal hippocampus; HCi2, ipsilateral ventral hippocampus (in EP mice) or medial entorhinal cortex (in PK mice). For detailed information see https://doi.org/10.7554/eLife.54518.