Number of deaths and mortality rate/100,000 person-years (95% confidence interval) by major disease/injury category according to principal, underlying, and immediate cause of death (COD).

aIncludes all ICD-10 codes not assigned to one of the other categories; examples include diabetes mellitus, all gastrointestinal diseases, hematologic diseases, etc.bIncludes 333 deaths that did not have death certificate information because they were identified from Social Security records, but not from the national death index (NDI), plus a small number of individuals identified from the NDI whose death certificate data were insufficient to assign a cause of death.cOne subject in the comparator group developed MS post-entry into the study.MS, multiple sclerosis.