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Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

NCATS Open Data2023-03-31 更新2026-08-08 收录

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蛋白酶抑制剂机制

数据链接：

https://doi.org/10.1101/2023.03.09.531862 数据链接链接失效反馈

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Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

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创建时间：

2023-03-09

药物发现

抗病毒药物研发

Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health em

NIAID Data Ecosystem100

Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor.

蛋白酶抑制剂机制

结构生物学

Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor. Descriptor: CALCIUM ION, Calpain-1 catalytic subunit, N~2~-[(2S)-2-{[(2R)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]AMINO}P

Protein Data Bank Japan2024-11-20 更新40

Room temperature X-ray structure of SARS-CoV-2 main protease in complex with compound Z1530724813

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蛋白质晶体结构解析

Room temperature X-ray structure of SARS-CoV-2 main protease in complex with compound Z1530724813 Descriptor: 2-(3-chlorophenyl)-N-(isoquinolin-4-yl)acetamide, 3C-like proteinase Authors: Kovalevsky,

Protein Data Bank Japan2023-10-18 更新40

Identification of a potential anti-viral drug targeting allosteric site of papain-like protease against rubella using a molecular modeling approach

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分子建模

Rubella virus (RUBV) is responsible for causing rashes, lymphadenopathy, and fever which are the hallmarks of an acute viral illness called Rubella. For RUBV replication, the non-structural polyprotei

DataCite Commons2026-03-02 更新60

Data_Sheet_2_Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity.pdf

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正痘病毒

Orthopoxviruses (OPXVs) are an increasing threat to human health due to the growing population of OPXV-naive individuals after the discontinuation of routine smallpox vaccination. Antiviral drugs that

NIAID Data Ecosystem40

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

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