Eco-evolutionary dynamics of anthelmintic resistance in soil-transmitted helminths

Anthelmintic resistance (AR) of helminth parasites against the most widely available drugs is an ongoing concern for both human and livestock-infecting species. Indeed, there has been substantial evidence of AR in livestock but less in humans, which may be due to a variety of reasons. In this paper, we develop an eco-evolutionary model that couples the life cycle of these parasites with their underlying evolution in a single biallelic genetic locus that confers resistance to treatment drugs. We determine the critical treatment frequency needed to effectively eliminate the population, for a fixed drug efficacy (without evolution) and use this to classify three qualitative distinct behaviors of the eco-evolutionary model. Then, we describe how aspects of the life cycle influence which qualitative outcome is achieved and the spread of the resistance allele, comparing across human- and livestock- infecting species. For all but one species, we find that lower fecundity rates and lower contac..., , , # Eco-evolutionary dynamics of anthelmintic resistance in soil-transmitted helminths

These data are created as a output of an eco-evolutionary model detailed in the manuscript. We ran a number of different model parameterizations and report the ecological dynamics (growth, rescue, or decline coded as 1, 2, and 3). Both Mathematica and R code include the same eco-evolutionary model and includes parameter values for all six helminth species.

## Description of the data and file structure

File list:
main_figures.R
SI_mathematica.nb
SI_mathematica.pdf
50grid_treatment.csv
50grid_treatment_res3.csv
50grid_parasite.csv
50grid_parasite_res.csv
50grid_parasite_mul.csv
50grid_parasite_mul_res.csv
50grid_host_v2.csv
50grid_host_v2_1_res.csv
50grid_host_subset.csv
50grid_host_subset_res3.csv

There are two sets of code. The Mathematica code (provided as SI_mathematica.nb and SI_mathematica.pdf) reproduces Figure 2 of the critical time between pulses as it depends on drug efficacy. The R code ...