Spexin as a potential biomarker for female infertility: insights into circulatory levels and genetic variants in Malaysian women

Female infertility is now a growing concern worldwide and is defined as the inability to get pregnant after a year of unprotected sexual intercourse. The complex interplay between advanced age, hormonal and structural abnormalities, lifestyle and genetic factors have contributed to the risk of infertility. Lately, a novel neuropeptide, Spexin has been implicated in reproductive dysfunction. Therefore, this study aims to unravel the relationship between Spexin and female infertility in humans by using genetic and immunoassay approach. The current findings underscore the potential of Spexin as a promising diagnostic marker as well as a therapeutic target for female infertility.