Expression data from U266 MM cells untreated or treated with trabectedn

Trabectedin triggered apoptosis in primary MM cells and MM cell lines in both 2D and 3D in vitro assays To shed light on molecular mechanisms underlying the anti-MM activity of trabectedin, modifications in the gene expression profile of U266 cells, untreated or treated with 2.5 nM of trabectedin for 24 h were evaluated. 3x10^6 U266 MM cells obtained from two different experiments were treated with PBS or 2.5 μM of trabectedin for 24 h. RNA extraction was then performed transcriptome profiles were evaluated by using Human transcriptom arrays from Affymetrix.