Transcriptome signature of WT and C3ar1-/-C5ar1-/- splenic DCs in response to CpG
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98315
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Our group showed that DC-instrinsic C3ar1/C5ar1 signals are required for TLR-initiated DC maturation in vivo. To more broadly analyze how local complement signaling affects DC maturation process in response to TLR9 stimulation, WT or C3ar1-/-C5ar1-/- mice were stimulated with CpG (i.v. 100 micrograms) or vehicle control. 4hrs later, splenic CD11c+DCs were isolated and RNAs from the cells were purified for microarray analyses. The experiment include samples from WT unstimulated DCs (n=2), WT CpG-stimulated DCs (n=3), C3ar1-/-C5ar1-/- unstimulated DCs (n=2), and C3ar1-/-C5ar1-/- CpG-stimulated DCs (n=3).
创建时间：
2021-07-25
