Proteogenomic profiling of thymic and pulmonary neuroendocrine neoplasia.. Proteogenomic profiling of thymic and pulmonary neuroendocrine neoplasia.

This study represents a proteogenomic resource for thymic and pulmonary neuroendocrine neoplasia (NEN) and provides a proteomgenomic diagnostic signature for classification of low and high grade NEN. Overall design: In this study, we characterized a cohort of 54 and 22 low and high grade NEN, respectively of both thymic and pulmonary origin by NanoString RNA analysis, NGS DNA Panel Sequencing analysis and MS-based proteomic analysis.