Raw data for hand and arm dysfunction following hemodialysis access placement

BACKGROUND: Patients with chronic or end-stage kidney disease (CKD/ESKD) often experience hand and arm dysfunction (HAD) following hemodialysis access placement, adversely affecting clinical outcomes and quality of life. Despite its prevalence, the underlying mechanisms of hemodialysis access-associated HAD remain largely unexplored. METHODS: We conducted a longitudinal study involving 30 patients with CKD/ESKD. Functional assessments, including grip strength, hand pressure, dexterity, sensory tests, and patient-reported HAD scores, were performed preoperatively and six weeks postoperatively. Brachioradialis muscle biopsies were analyzed for morphology, mitochondrial function, and transcriptomic profiles. Routine follow-up assessments were performed to determine functional hemoaccess success. RESULTS: Six weeks post-surgery, patients exhibited significant functional decline in the access limb. Postoperative grip strength declined by approximately 15% (P=0.0015), finger pressure decreased by ~30 mmHg (P