Clinical performance of the DNA methylation biomarkers SHOX2 and SEPT9 and cytology in PEs from 114 patients.

Positive test results are labelled “+”, cytologically suspicious for malignancy were labelled by “(+)”. Negative test results are labelled by “–”. Invalid test results due to low DNA content are shown as “nd”. The results classified as “(+)” and “nd” were used equivalently to negative test results in the calculation of positivity and specificity.