Summary ORs (95% CI) and value of the heterogeneity of XRCC1 Arg399Gln polymorphism under different genetic models according to studies with HWE on cancer risk1.

1all summary ORs were calculated using fixed-effects models. In the case of significant heterogeneity (indicated by *), ORs were calculated using random-effects models;2examine genotype frequencies in the controls, significant deviation from HWE was detected in the eight studies. These studies were only breast cancer, bladder cancer, skin cancer, head and neck cancer, prostate cancer, hepatocellular cancer, esophageal cancer. Hence, only these cancers were analyzed. Cancer comparisons add up to 158 (which should be 289) because the remaining 131 comparisons were 6 cervical cancer, 27 colorectal cancer, 15 gastric cancer, 7 glioma, 15 leukemia, 41 lung cancer, 4 lymphoma, 6 pancreatic cancer, and 9 other cancer; HWE hardy–weinberg equilibrium; the bold values indicate that the results are statistically significant.